Endocrine Abstracts

Patients with craniopharyngioma are frequently obese with a high prevalence of vascular morbidity. Many patients with treated craniopharyngioma have severe GH deficiency (GHD), which independently results in abnormal body composition and increased cardiovascular risk. This study investigated how GH treatment influences body composition in adults with treated craniopharyngioma and GHD.Using the electronic database Diabeta3® we identified 50 patients ...

Klinefelter syndrome (47XXY male) (KS) is the most common sex chromosome disorder in men. The phenotype is diverse including: infertility, hypogonadism, impaired cognition, behavior disorders, increased autoimmunity and osteopenia. We have studied osteopenia, learning dysfunction, germ cell loss, and testosterone deficiency in 41 XXY mice bred by two separate methods. We have characterized the germ cell loss by apoptosis and germ cell migration as the mice progress from day 1 ...

Objective: Metformin was considered as a weight lowering agent in diabetes patients, while it remained unclear in simple obesity patients. We aimed to investigate if metformin is effective and safe in the therapy of normoglycemic obesity.Methods: We systematically searched MEDLINE (1950–2011), EMBase (1950–2011), and CCTR (4th Issue 2011), and collected and screened all randomized controlled trials compared metformin and placebo in obese partic...

The hypothalamic melanocortin system is a regulator of energy homeostasis. Chronic CNS administration of Agouti related peptide (Agrp) causes increased food intake, increased body adiposity, an inhibition of the HPT axis and a suppression of BAT UCP-1. The ability of Agrp to alter oxygen consumption, a measure of energy expenditure, is unknown.Chronic daily ICV administration of Agrp (1nmol) caused a 54% increase in food intake (food intake, day 7: Agrp...